Prague has very few genuine round-the-clock (nonstop) pharmacies — most close in the evening, and at night medicine is only dispensed by a handful of on-duty pharmacies, often through a night window with a buzzer. Below are real pharmacies that operate 24/7 or late into the night, complete with addresses and phone numbers, plus tips on how to find the nearest on-duty pharmacy (pohotovostní lékárna). Tip: call ahead before a night trip — opening hours and pharmacist availability sometimes change.
Prague has very few genuine round-the-clock (nonstop) pharmacies — most close in the evening, and at night medicine is only dispensed by a handful of on-duty pharmacies, often through a night window with a buzzer. Below are real pharmacies that operate 24/7 or late into the night, complete with addresses and phone numbers, plus tips on how to find the nearest on-duty pharmacy (pohotovostní lékárna). Tip: call ahead before a night trip — opening hours and pharmacist availability sometimes change.
A genuine 24/7 pharmacy, open every day of the week, right in the historic centre near Staroměstská. Convenient for tourists and residents of the city centre. At night the hospital's main entrance is locked — you need to ring the buzzer by the door; emergency phone +420 771 273 479. Prescription medicine can be ordered online and picked up at any time.
Address: Na Františku 847/8, Praha 1 – Staré Město
Phone: +420 222 801 397
Website: https://www.nnfp.cz/lekarna/lekarna-na-frantisku/
A pharmacy with a round-the-clock on-duty window (pohotovostní okénko) in Vinohrady, close to Míru Square. At night and on weekends, medicine is handed out through the window. One of the few nonstop pharmacies in the central part of the city, it also compounds medicine to prescription.
Address: Belgická 238/37, Praha 2 – Vinohrady
Phone: +420 222 513 396
Website: https://www.lekbelgicka.cz/
A 24-hour pharmacy on the grounds of FN Motol, the largest hospital in Czechia (children's building, the low blue administration building). Handy if you're already at Motol Hospital or live in western Prague. Second phone line: +420 224 435 721. Nearest metro: Nemocnice Motol (line A).
Address: V Úvalu 84, Praha 5 – Motol
Phone: +420 224 435 736
Website: https://www.fnmotol.cz/
A pharmacy with round-the-clock on-duty service at Thomayer University Hospital in southern Prague (Krč). Open every day, including holidays. Outside regular hours, ring the buzzer at the door (the left-hand door). Convenient for residents of Prague 4 and Prague 12.
Address: Vídeňská 800, Praha 4 – Krč
Phone: +420 261 084 019
Website: https://www.ftn.cz/lekarna-50/
A BENU pharmacy in Holešovice with round-the-clock on-duty service, including weekends. During the day it's a regular pharmacy floor; in the evening and at night medicine is only dispensed through the window. Convenient for Prague 7 and the northern part of the centre.
Address: Františka Křížka 683/22, Praha 7 – Holešovice
Phone: +420 212 812 811
Website: https://www.benu.cz/lekarna-benu-praha-7-fr-krizka
A 24-hour Dr. Max pharmacy on Vítězné náměstí (Kulaťák), near Dejvická metro station (line A). Convenient for residents of Prague 6 and the north-west of the city. Check the phone number on drmax.cz; it's also worth double-checking that 24/7 hours are still in effect before a night visit.
Address: Vítězné náměstí 997/13, Praha 6 – Bubeneč / Dejvice
Website: https://www.drmax.cz/
A pharmacy at the EUC clinic in Malešice with round-the-clock (nonstop) hours — one of the few in eastern Prague. Convenient for Prague 10 and neighbouring districts. Check the exact phone number on euc.cz or via a maps search before heading over.
Address: Plaňanská 1, Praha 10 – Malešice
Website: https://www.euc.cz/
A pharmacy at the EUC clinic in Chodov with round-the-clock hours — convenient for south-east Prague (Prague 11/4), near Chodov/Opatov metro stations. It's best to confirm the phone number and current hours in advance on euc.cz.
Address: Šustova 1930/2, Praha 4 – Chodov
Website: https://www.euc.cz/
Important: round-the-clock night service at the Bulovka pharmacy has been discontinued due to a shortage of pharmacists. It currently operates roughly Mon–Fri 7:00–20:00, Sat–Sun 8:00–20:00, with on-duty dispensing until 22:00–23:00. Do NOT count on it at night — we're including it here so you don't make a wasted trip. For night-time needs, choose Na Františku, U sv. Ludmily, or Motol instead.
Address: Budínova 67/2, Praha 8 – Libeň (Nemocnice Na Bulovce)
Phone: +420 266 082 017
Website: https://bulovka.cz/kliniky-a-oddeleni/lekarna
A list of pharmacies with night/round-the-clock service is maintained by the Czech Chamber of Pharmacists (lekarnici.cz), as well as by the aggregators leano.cz and nonstop-lekarna.cz, which show what's open right now. In an emergency, call 155 (ambulance) or 112. There are only a handful of such pharmacies across Prague, so before a night trip check the current hours by phone or on the website — hours change due to pharmacist shortages.
Address: All of Prague and Czechia
Phone: 155
Website: https://lekarnici.cz/lekarny-s-pohotovostni-sluzbou-24-7/
This information is for reference only; phone numbers, addresses and opening hours may change — please check with the official websites of the facilities.
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